STEM CELL REGENERATIVE MEDICINE is a promising approach to treat cartilage lesions and clinical benefits have been reported in a number of studies. STEM CELL REGENERATIVE MEDICINE is performed using injectable vehicles including platelet-rich plasma (PRP), hyaluronic acid (HA), and birth tissue containing mesenchymal stem cells (MSC) and many other regenerative cellular components. No adverse events and promising clinical outcomes are constantly reported, demonstrating the extraordinary benefits of using these injectable systems for the treatment of cartilage lesions and osteoarthritis.